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Layer-fMRI and predictive processing¶

How does cortex implement predictive processing — separating bottom-up sensory drive from top-down cognitive modulation? We use submillimeter 7T laminar fMRI to test layer-specific computations in human pain processing.

Key study¶

Kincses et al. — Layer-specific cortical processing dissociates sensory and cognitive influences on pain

Using a factorial manipulation of nociceptive input and cognitive (distraction) modulation, bottom-up processing was strongest in middle cortical layers, whereas top-down modulation preferentially engaged superficial layers — consistent with cortico-cortical feedback. Individual differences in this laminar segregation predicted distraction-induced analgesia, linking circuit architecture to behaviour.

Resources¶

• Preprint: Kincses et al. (2026)

• Analysis pipeline: github.com/kincsesbalint/LaminarfMRI_inPainPerception